Beilstein J. Org. Chem.2020,16, 798–808, doi:10.3762/bjoc.16.73
, China College of Pharmacy, Jinzhou Medical University, Jinzhou, 121001, China College of Pharmacy, Jiamusi University, Jiamusi, 154007, China 10.3762/bjoc.16.73 Abstract In the present study, a practical method to prepare piperazinylamides of 18β-glycyrrhetinic acid was developed. Two main procedures
conditions. Furthermore, the reasons for the appearance of byproducts were elucidated. Crystallographic data of a selected piperazinyl amide is reported.
Keywords: 18β-glycyrrhetinic acid; piperazinylamides; synthesis; Introduction
Glycyrrhizin was the major bioactive component in Glycyrrhiza uralensis
two methods are complicated through the side formation of bisamide, obviously, due to the competitive attack on the N atoms of the symmetric diamine. An alternative method [12] to prepare such piperazinylamides (c) involves the amidation of 18β-glycyrrhetinic acid with 4-substituted phenylpiperazines
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Graphical Abstract
Figure 1:
Chemical structure of 18β-glycyrrhetinic acid and known derivatives.